Phase-Amplitude Coupling in Theta and Beta Bands: A Potential Electrophysiological Marker for Obstructive Sleep Apnea
OSA patients demonstrated increased MI values of theta phase and beta amplitude in the frontal and occipital regions during N1 sleep and wakefulness. This suggests that cortical coupling is prevalent and exhibits sleep-stage-specific patterns in OSA. Theta-beta PAC during N1 and wakefulness was positively correlated with hypoxia-related indices, suggesting a potential relationship between these neural oscillations and OSA severity. The present study provides new insights into the relationship between neural oscillations and respiratory hypoxia in OSA patients.
Authors
- Changhe Shi (ORCID: https://orcid.org/0000-0002-4843-0072)
- Peng‐Peng Niu (ORCID: https://orcid.org/0000-0002-5943-9654)
- Shuo Li (ORCID: https://orcid.org/0000-0003-2331-2448)
- Yusheng Li (ORCID: https://orcid.org/0000-0003-2437-0295)
- Chan Zhang (ORCID: https://orcid.org/0000-0002-1808-3153)
- Mengjie Li (ORCID: https://orcid.org/0000-0002-0619-8754)
- Zhuopeng Hu (ORCID: https://orcid.org/0009-0000-2824-9957)
- Yanhui Wang (ORCID: https://orcid.org/0009-0003-0813-1726)
Institutions
- Henan University of Technology (CN)
- Zhengzhou University (CN)
- First Bethune Hospital of Jilin University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Henan Provincial Center for Disease Control and Prevention (CN)
Publication Details
- Journal
- Nature and Science of Sleep
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/nss.s470617
- Citations
- 5
- Primary Topic
- Obstructive Sleep Apnea Research
- Type
- article
- Field-Weighted Citation Impact
- 1.63
Funders
- National Natural Science Foundation of China