Tetrabenazine, a vesicular monoamine transporter 2 inhibitor, inhibits vesicular storage capacity and release of monoamine transmitters in mouse brain tissue
Our observations provide neurochemical evidence explaining the mechanism of VMAT-2 inhibitors in the brain and support the involvement of dopaminergic and noradrenergic transmission in hyperkinetic movement disorders.
Authors
- Beáta Sperlágh (ORCID: https://orcid.org/0000-0003-0099-591X)
- Balázs Lendvai (ORCID: https://orcid.org/0000-0001-9289-4715)
- Pál Tod (ORCID: https://orcid.org/0000-0001-9163-7071)
- E. Sylvester Vizi (ORCID: https://orcid.org/0000-0002-9557-4597)
- Viktor Román (ORCID: https://orcid.org/0000-0002-4849-3591)
- Anita Varga (ORCID: https://orcid.org/0009-0007-2920-2641)
- Roland Pálkovács (ORCID: https://orcid.org/0000-0002-3677-6260)
Institutions
- Semmelweis University (HU)
- Gedeon Richter (Hungary) (HU)
- HUN-REN Institute of Experimental Medicine (HU)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1111/bph.17348
- Citations
- 5
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.34
Funders
- European Commission