Evaluation of chemotherapy toxicities in patients receiving treatment for gastrointestinal cancers and therapeutic monitoring of 5‐fluorouracil as a clinical support tool
These findings suggest that the evaluation of DPYD genotyping and DPD phenotyping in the Brazilian population still requires further study. Moreover, the analysis of the plasma AUC of 5-FU could contribute to clinical routine, being a very useful tool, especially for identifying patients outside the therapeutic range and thus guiding more individualized doses, or even in the intervention of possible toxicities related to overexposure.
Authors
- Sylvio Elvis Da Silva Barbosa
- Laura Cé da Silva
- Marina Venzon Antunes (ORCID: https://orcid.org/0000-0001-9157-9510)
- Mauber Eduardo Schultz Moreira
- Lucas Silva de Baco (ORCID: https://orcid.org/0000-0003-0213-7353)
- Natália Brucker (ORCID: https://orcid.org/0000-0003-0632-7955)
- Rafael Linden (ORCID: https://orcid.org/0000-0002-6966-5073)
- Luís Carlos Moreira Antunes (ORCID: https://orcid.org/0000-0002-4544-2123)
- Sarayane Araújo Brandão Maranhão
- Lucimara Volpato
- Lauren Razzera Stefanon
- Ricardo Bolsson Radins
Institutions
- Universidade Feevale (BR)
- Universidade Federal de Santa Maria (BR)
- Hospital Universitário de Santa Maria (BR)
Publication Details
- Journal
- Fundamental and Clinical Pharmacology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1111/fcp.13037
- Citations
- 2
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Hospital Universiti Sains Malaysia