Insulin‐like growth factor‐1 in cirrhosis is linked to hepatic dysfunction and fibrogenesis and predicts liver‐related mortality
Decreased levels of IGF-1 reflect impaired hepatic function and fibrogenesis in patients with cirrhosis, which seems particularly relevant in obesity since low IGF-1 was independently linked to high BMI. Lower IGF-1 in cirrhosis predicts decompensation, ACLF and liver-related death.
Authors
- Peter Wolf (ORCID: https://orcid.org/0000-0001-6779-734X)
- Mattias Mandorfer (ORCID: https://orcid.org/0000-0003-2330-0017)
- David Bauer (ORCID: https://orcid.org/0000-0002-9363-8518)
- Michael Schwarz (ORCID: https://orcid.org/0000-0002-2587-1385)
- Nina Dominik (ORCID: https://orcid.org/0009-0009-4615-915X)
- Benedikt Simbrunner (ORCID: https://orcid.org/0000-0001-8181-9146)
- Lukas Hartl (ORCID: https://orcid.org/0000-0003-3398-6120)
- Bernhard Scheiner (ORCID: https://orcid.org/0000-0002-4904-5133)
- Georg Semmler (ORCID: https://orcid.org/0000-0002-0411-166X)
- Thomas Reiberger (ORCID: https://orcid.org/0000-0002-4590-3583)
- Benedikt Silvester Hofer (ORCID: https://orcid.org/0000-0003-3403-3372)
- Rodrig Marculescu (ORCID: https://orcid.org/0000-0003-1772-6695)
- Mathias Jachs (ORCID: https://orcid.org/0000-0003-2871-4147)
- Michael A Trauner (ORCID: https://orcid.org/0000-0002-1275-6425)
- Lorenz Balcar (ORCID: https://orcid.org/0000-0002-6708-3061)
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- Alimentary Pharmacology & Therapeutics
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1111/apt.18289
- Citations
- 13
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.03
Funders
- Ludwig Boltzmann Gesellschaft