EGCG inhibits migration, invasion and epithelial-mesenchymal transition of renal cell carcinoma by activating TFEB-mediated autophagy
In conclusion, these findings demonstrate for the first time that EGCG inhibits migration, invasion, and EMT of RCC by activating TFEB-mediated autophagy. Therefore, the combination of EGCG and TFFB activators or EMT inhibitors is expected to be a promising therapeutic strategy for RCC.
Authors
- Bixin Yu
- Taotao Que
- Bo Liu (ORCID: https://orcid.org/0000-0002-1395-9152)
- Yujiao Zhang (ORCID: https://orcid.org/0000-0002-8820-1602)
- Lei Luo
Institutions
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- University of South China (CN)
Publication Details
- Journal
- Chemico-Biological Interactions
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.cbi.2024.111250
- Citations
- 10
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 3.87