Manejo atual da doença pulmonar obstrutiva crônica: abordagens terapêuticas e novas perspectivas

Chronic Obstructive Pulmonary Disease (COPD) is a highly prevalent chronic respiratorycondition characterized by progressive and irreversible airflow limitation. It is associated withsignificant morbidity, with frequent exacerbations that increase hospitalization rates andworsen patients' quality of life. This study reviews the latest therapeutic approaches in COPDmanagement, including pharmacological interventions such as long-acting bronchodilators,inhaled corticosteroids, and biological agents, as well as non-pharmacological strategies suchas smoking cessation and pulmonary rehabilitation. Following an initial search of 6,973studies, 32 articles were reviewed, leading to the inclusion of 9 key studies. The resultsindicate that personalized treatment, combining medications and behavioral interventions,improves lung function and reduces exacerbations. Interventions such as short-durationantibiotic and systemic corticosteroid regimens proved effective in managing acuteexacerbations, while the use of non-invasive ventilation during the COVID-19 pandemic wasshown to be a viable alternative for COPD patients. It is concluded that COPD managementrequires a multidisciplinary and personalized approach to optimize disease control and reducelong-term complications.