Differential plasma cytokine variation following X-ray or proton brain irradiation using machine-learning approaches
Our findings revealed distinct inflammatory responses induced by X-ray irradiation in contrast to proton brain irradiation, as demonstrated by the differential regulation of cytokines in the bloodstream. Moreover, the study highlighted the association between specific cytokine levels and various leukocyte subpopulations. Further investigation is essential to accurately determine the impact of proton and X-ray brain irradiation on the inflammatory response and the efficacy of radiotherapy treatment.
Authors
- Viktoriia Ivanova (ORCID: https://orcid.org/0000-0002-2437-6403)
- Juliette Thariat (ORCID: https://orcid.org/0000-0003-4755-496X)
- Julie Coupey
- Samuel Valable (ORCID: https://orcid.org/0000-0003-0355-0270)
- Thao-Nguyen Pham
Institutions
- Centre National de la Recherche Scientifique (FR)
- Normandie Université (FR)
- Laboratoire de Physique Corpusculaire de Caen (FR)
- Cyceron (FR)
- Imagerie et Stratégies Thérapeutiques pour les Cancers et Tissus cérébraux (FR)
- Université de Caen Normandie (FR)
Publication Details
- Journal
- Cancer/Radiothérapie
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.canrad.2024.08.001
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.29
Funders
- Agence Nationale de la Recherche
- Ligue Contre le Cancer
- Centre National de la Recherche Scientifique
- Région Normandie