High hemolytic activity in Staphylococcus aureus t1081/ST45 due to increased hla protein production and potential RNAIII-independent regulation
Our study revealed that, compared with other CC45 isolates, the t1081/ST45 isolates presented greater hemolytic activity. This heightened activity was due mainly to increased Hla protein levels. Moreover, the higher translation levels may be independent of the known regulator RNAIII, indicating a potential RNAIII-independent mechanism for Hla regulation.
Authors
- Tai-Fen Lee
- Po‐Ren Hsueh (ORCID: https://orcid.org/0000-0002-7502-9225)
- Cheng‐Wen Lin (ORCID: https://orcid.org/0000-0003-0165-2652)
- Yu-Tzu Lin (ORCID: https://orcid.org/0000-0002-3815-6305)
- Ngoc-Niem Bui (ORCID: https://orcid.org/0000-0003-0928-791X)
- C.-M. Lee
- Yu-Syuan Cheng
Institutions
- Can Tho University (VN)
- China Medical University (TW)
- China Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Journal of Microbiology Immunology and Infection
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.jmii.2024.09.005
- Citations
- 3
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Ministry of Science and Technology, Taiwan
- China Medical University
- China Medical University, Taiwan