Aspergillus fumigatus extract modulates human eosinophils via NOD2 and oxidative stress
A. fumigatus modulates human eosinophils via NOD2 and oxidative stress-mediated signaling. NOD2 signaling potentiated IL-5-induced activation, suggesting its pathogenic role in type 2 inflammation. NOD2 inhibitors and antioxidants can have therapeutic potential against A. fumigatus-related allergic disorders.
Authors
- Yoshinori Hasegawa (ORCID: https://orcid.org/0000-0003-2904-6611)
- Yo Otsu (ORCID: https://orcid.org/0000-0003-2828-5063)
- Keeya Sunata (ORCID: https://orcid.org/0000-0002-1694-8432)
- Yusuke Kawashima (ORCID: https://orcid.org/0000-0002-9779-8199)
- M. Ishikawa (ORCID: https://orcid.org/0000-0002-3101-6713)
- Yoshifumi Kimizuka (ORCID: https://orcid.org/0000-0002-4026-7506)
- Katsunori Masaki (ORCID: https://orcid.org/0000-0003-0909-9409)
- Ryo Konno (ORCID: https://orcid.org/0000-0002-4375-1133)
- Emiko Matsuyama (ORCID: https://orcid.org/0000-0002-9822-6184)
- Hiroki Kabata (ORCID: https://orcid.org/0000-0001-8853-6149)
- Akihiko Kawana
- Shigeharu Ueki (ORCID: https://orcid.org/0000-0002-3537-7735)
- Hisashi Sasaki (ORCID: https://orcid.org/0000-0001-7642-2451)
- Jun Miyata (ORCID: https://orcid.org/0000-0002-3189-1702)
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Koichiro Asano (ORCID: https://orcid.org/0000-0002-9044-3061)
- Ryuta Onozato
- Tomoe Abe
Institutions
- Tokai University (JP)
- Akita University (JP)
- Keio University (JP)
- Kazusa DNA Research Institute (JP)
- National Defense Medical College (JP)
Publication Details
- Journal
- Allergology International
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.alit.2024.08.009
- Citations
- 6
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.96