Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro
The results of our study confirmed that the antipsychotropic drugs ritanserin and duloxetine alter PAX6 and TGF-β1 gene expression in AN-LSCs cultured in LGSF-medium. These drugs were found to have an impact on retinoic acid signaling pathways and keratocyte characteristic markers both in LSCs and AN-LSCs, using different culture media.
Authors
- Tanja Stachon (ORCID: https://orcid.org/0000-0001-7009-7125)
- Zhen Li (ORCID: https://orcid.org/0000-0001-5491-2169)
- Maryam Amini (ORCID: https://orcid.org/0009-0000-3118-9959)
- Shweta Suiwal (ORCID: https://orcid.org/0000-0002-1230-1279)
- Nóra Szentmáry (ORCID: https://orcid.org/0000-0001-8019-1481)
- Fabian Norbert Fries (ORCID: https://orcid.org/0000-0002-8526-4712)
- Berthold Seitz (ORCID: https://orcid.org/0000-0001-9701-8204)
- Lei Shi (ORCID: https://orcid.org/0000-0001-5105-8374)
- Ning Chai (ORCID: https://orcid.org/0000-0001-9689-8887)
Institutions
- Anhui Provincial Hospital (CN)
- Saarland University (DE)
Publication Details
- Journal
- Ophthalmology and Therapy
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1007/s40123-024-01032-8
- Citations
- 7
- Primary Topic
- Developmental Biology and Gene Regulation
- Type
- article
- Field-Weighted Citation Impact
- 1.64