Abstract B114: Enhancing understanding and engagement: Investigating the impact of education on clinical trial participation

Abstract Institutions: Thomas Jefferson University Department of Oncology Funded by: NIH/NCI 3P30CA056036-22S1 Background Clinical trials (CT) advance knowledge in cancer care. Access to CT may be facilitated by patient knowledge. We evaluated the impact of a tailored CT educational video intervention via a pre- and post-test survey on CT interest and enrollment. Methods Participants included persons with cancer (PwCa) as well as persons without cancer—general population (GP). A McNemar test was used to assess the differences in survey scores for patients knowledge (11 questions) and intention-to-participate in future CT (6 questions). Results 363 (GP) and 116 (PwCa) participated; 178 and 55 participants completed both pre- and post-surveys, respectively. GP: 148 (70%) men, 58 (28%) women, 2 (1%) transgender, 2 (1%) non-binary; white, non-Latinx 125 (60%), Black 60 (29%), Asian 2 (1%), Latinx 52 (25%). PwCa: 48 (47%) men, 48 (53%) women; white, non-Latinx 71 (79%), Black 8 (9%), Asian 7 (7%), Latinx 5 (6%).The mean age was 30 yrs (sd: 7 yrs) [GP] and 55 yrs (sd: 17.8 yrs) [PwCa]. PwCa scores significantly improved for “In a CT, a patient will always get the new medicine or treatment being tested” (p=0.003). GP scores significantly improved for “You can only join a CT after you have tried all other options (p=0.002)”, “CTs test whether a new medicine or treatment works (p=0.031)” and “Once I sign a consent form, I must stay in the CT until my doctor tells me I'm done (p=0.0001).” The intention to participate in CT improved significantly in PwCa (p<0.05). The intention to gain more information about CT from their physicians and discussing CT with family (p<0.05) improved significantly in GP. Conclusions The tailored educational intervention significantly impacted PwCa’s intention to participate in CT and GP’s intention to learn more about CT and to share the CT information learned. The GP group was more diverse. Ongoing research is monitoring whether PwCa participants enroll in a CT, thereby assessing the long-term impact of the educational intervention on decision-making regarding CT participation taking into account CT availability and eligibility. Citation Format: Jesutomisola Onafowokan, FNU Nikita, Iqra Siddiqui, Ana Maria Lopez. Enhancing understanding and engagement: Investigating the impact of education on clinical trial participation [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B114.