Abstract A023: Immune-related diseases and skin cancer in a racially and ethnically diverse US-based population

Abstract Though the immune system plays a crucial role in skin cancer development, associations between immune-related diseases and skin cancer have not been well studied in racial and ethnic minorities. The goal of this cross-sectional study was to assess the relationship between various immune-related diseases and basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and cutaneous malignant melanoma (MM) diagnoses within the diverse “All of Us” Research Program cohort. It included 307,451 adult participants with electronic health record (EHR) data enrolled from 2017-2023. Participant EHRs were used to determine immune-related diseases and skin cancer diagnoses. Multivariate logistic regression analyses were adjusted for demographic characteristics, lifestyle factors such as smoking history, in addition to health insurance status, educational attainment, history of photosensitivity, history of organ transplant, as well as UV exposure at residence. R v4.0.5 was utilized to conduct the analysis. 8,107 participants with BCC, 4,102 with SCC and 2,461 with MM were identified. Personal history of any immune-related disease was significantly associated with all skin cancer types (odds ratio and 95% confidence intervals -- BCC: 1.27 [1.20-1.33]; SCC:1.38 [1.29-1.49]; MM: 1.55 [1.42-1.69]). Rheumatoid arthritis, hypothyroidism, type I diabetes, Crohn’s disease, and ulcerative colitis were each associated with the three skin cancer types. Multiple sclerosis, Sjogren’s syndrome, hyperthyroidism, dermatomyositis/polymyositis, vitiligo, and psoriasis were associated with at least one skin cancer. Systemic lupus, scleroderma, alopecia areata, and atopic dermatitis were not associated with any skin cancer. In non-White participants alone (n=133,144; 43.3%), history of any immune-related disease was similarly significantly associated with all three skin cancer types. These findings suggest that the history of several immune-related diseases is associated with skin cancer, including among racial/ethnic minorities, and thus increased skin cancer surveillance in these patient populations may be indicated. Citation Format: Erica M. Lin, Sara Ragi, Rachel Lim, Shirley Lin, Isabelle Moseley, Abrar Qureshi, Eunyoung Cho. Immune-related diseases and skin cancer in a racially and ethnically diverse US-based population [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr A023.