Abstract B087: Inflammation and breast cancer: Understanding the interplay and implications for prevention and treatment

Abstract Breast cancer continues to be a major global health issue, affecting millions and posing challenges for researchers and healthcare workers. Recent research has revealed the importance of inflammation in the development and progression of a variety of malignancies, including breast cancer. The aim of this study is to investigate the complex association between inflammation and breast cancer in order to improve treatment and preventative techniques. A mixed-methods approach was used, with both quantitative and qualitative studies. The study included 580 breast cancer patients and 2,573 control participants. Patient records, hospital databases, and publicly available datasets were all used as data sources. Statistical methods, including univariate and multivariate logistic regression models, were employed to discover breast cancer predictors associated with inflammation. Breast cancer growth is strongly linked to chronic inflammation and specific inflammatory markers (CRP, IL-6, and TNF-α). Breast cancer incidence is correlated with geographical, demographic, and lifestyle characteristics such as region, age, gender, race, education level, and overall health condition. Comorbidities like hypertension, diabetes, and arthritis, as well as BMI, smoking, and physical activity levels, all have a role in risk. Anti-inflammatory drugs and lifestyle changes show promise for lowering the risk of breast cancer and improving patient outcomes. The study reveals significant relationships between breast cancer incidence and a variety of demographic, lifestyle, and health-related variables. Chronic inflammation is important in the development of breast cancer; therefore, inflammatory indicators could be used as diagnostic or therapeutic tools. The study suggests that tailored anti-inflammatory medications and lifestyle changes could have a significant impact on breast cancer prevention and therapy. This study emphasizes the necessity of knowing the relationship between inflammation and breast cancer. The insights revealed can lead to novel methods for breast cancer management, stressing the importance of ongoing research to fully understand the connection between inflammation and breast cancer and to implement these discoveries in clinical practice. Citation Format: Opeyemi O. Ogungbola, Samuel O. Ejeh, Jane Odeh, Olajumoke R. Omoniyi, Abayomi A. Akomolafe, Emmanuel K. Abudu. Inflammation and breast cancer: Understanding the interplay and implications for prevention and treatment [abstract]. In: Proceedings of the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2024 Sep 21-24; Los Angeles, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2024;33(9 Suppl):Abstract nr B087.