Quantifying brain development in the HEALthy Brain and Child Development (HBCD) Study: The magnetic resonance imaging and spectroscopy protocol
The HEALthy Brain and Child Development (HBCD) Study, a multi-site prospective longitudinal cohort study, will examine human brain, cognitive, behavioral, social, and emotional development beginning prenatally and planned through early childhood. The acquisition of multimodal magnetic resonance-based brain development data is central to the study's core protocol. However, application of Magnetic Resonance Imaging (MRI) methods in this population is complicated by technical challenges and difficulties of imaging in early life. Overcoming these challenges requires an innovative and harmonized approach, combining age-appropriate acquisition protocols together with specialized pediatric neuroimaging strategies. The HBCD MRI Working Group aimed to establish a core acquisition protocol for all 27 HBCD Study recruitment sites to measure brain structure, function, microstructure, and metabolites. Acquisition parameters of individual modalities have been matched across MRI scanner platforms for harmonized acquisitions and state-of-the-art technologies are employed to enable faster and motion-robust imaging. Here, we provide an overview of the HBCD MRI protocol, including decisions of individual modalities and preliminary data. The result will be an unparalleled resource for examining early neurodevelopment which enables the larger scientific community to assess normative trajectories from birth through childhood and to examine the genetic, biological, and environmental factors that help shape the developing brain.
Authors
- Ralph Noeske (ORCID: https://orcid.org/0000-0002-6193-366X)
- Joshua Kuperman (ORCID: https://orcid.org/0000-0002-7890-4785)
- Timothy Hendrickson (ORCID: https://orcid.org/0000-0001-6862-6526)
- Ai Wern Chung (ORCID: https://orcid.org/0000-0002-0905-6698)
- Tom Hilbert (ORCID: https://orcid.org/0000-0001-8207-4908)
- Jed T. Elison (ORCID: https://orcid.org/0000-0002-6246-1000)
- Alan C. Evans (ORCID: https://orcid.org/0000-0003-3841-6098)
- Eun-Kyung Shin (ORCID: https://orcid.org/0000-0002-5353-9259)
- Steven Kecskemeti (ORCID: https://orcid.org/0000-0003-3589-430X)
- Xiawei Ou (ORCID: https://orcid.org/0000-0001-9815-0127)
- Tracy Riggins (ORCID: https://orcid.org/0000-0002-8633-2131)
- Kimberly B. Weldon (ORCID: https://orcid.org/0000-0003-4349-9916)
- Helge J. Zöllner (ORCID: https://orcid.org/0000-0002-7148-292X)
- Borjan Gagoski (ORCID: https://orcid.org/0000-0003-3777-2621)
- Aaron T. Gudmundson (ORCID: https://orcid.org/0000-0001-5104-0959)
- Andrew R. Mayer (ORCID: https://orcid.org/0000-0003-2396-5609)
- Georg Oeltzschner (ORCID: https://orcid.org/0000-0003-3083-9811)
- Eric Feczko (ORCID: https://orcid.org/0000-0003-1337-5517)
- Brittany Howell (ORCID: https://orcid.org/0000-0002-5643-2326)
- Lucille A. Moore (ORCID: https://orcid.org/0000-0002-7665-2713)
- Banu Ahtam (ORCID: https://orcid.org/0000-0003-2036-092X)
- William T. Clarke (ORCID: https://orcid.org/0000-0001-7159-7025)
- Arvind Caprihan (ORCID: https://orcid.org/0000-0002-4810-359X)
- Lisa S. Scott (ORCID: https://orcid.org/0000-0002-8136-891X)
- Peter C.M. van Zijl (ORCID: https://orcid.org/0000-0002-9706-1066)
- Essa Yacoub (ORCID: https://orcid.org/0009-0000-1007-9056)
- Michael P. Harms (ORCID: https://orcid.org/0000-0001-7945-036X)
- Mary Kate Manhard (ORCID: https://orcid.org/0000-0001-5374-9988)
- Dan Rettmann (ORCID: https://orcid.org/0000-0002-0117-1851)
- Richard A.E. Edden (ORCID: https://orcid.org/0000-0002-0671-7374)
- M. Okan İrfanoğlu (ORCID: https://orcid.org/0000-0001-8351-1516)
- Damien A. Fair (ORCID: https://orcid.org/0000-0001-8602-393X)
- Sharlene D. Newman (ORCID: https://orcid.org/0000-0002-5575-8535)
- Russell A. Poldrack (ORCID: https://orcid.org/0000-0001-6755-0259)
- Steve C. N. Hui (ORCID: https://orcid.org/0000-0002-1523-4040)
- Andrew L. Alexander (ORCID: https://orcid.org/0000-0003-2695-768X)
- Bidhan Lamichhane (ORCID: https://orcid.org/0000-0001-7655-4681)
- Yansong Zhao (ORCID: https://orcid.org/0000-0003-4639-7704)
- Wei Gao (ORCID: https://orcid.org/0000-0002-9260-2601)
- Christopher D. Smyser (ORCID: https://orcid.org/0000-0002-4716-5190)
- Mary Beth Nebel (ORCID: https://orcid.org/0000-0003-0185-3382)
- Matthew Cieslak (ORCID: https://orcid.org/0000-0002-1931-4734)
- Natacha Beck
- Kahini Mehta (ORCID: https://orcid.org/0000-0001-9466-100X)
- Saipavitra Murali‐Manohar (ORCID: https://orcid.org/0000-0002-4978-0736)
- Douglas Dean (ORCID: https://orcid.org/0000-0002-7057-1285)
- Cristian Navarro
- Chad M. Sylvester (ORCID: https://orcid.org/0000-0003-2154-0826)
- Jennifer Vannest (ORCID: https://orcid.org/0000-0001-7888-0245)
- Leigh MacIntyre
- Sergiy Boroday
- James J. Pekar (ORCID: https://orcid.org/0000-0002-9830-0655)
- Sandeep Ganji (ORCID: https://orcid.org/0000-0002-0247-7596)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Todd B. Parrish (ORCID: https://orcid.org/0000-0002-1184-1572)
- Yulu Song (ORCID: https://orcid.org/0000-0002-4416-7959)
- Carlo Pierpaoli (ORCID: https://orcid.org/0000-0001-8558-4428)
- Tobias Kober (ORCID: https://orcid.org/0000-0001-7598-9456)
- Christopher W. Davies‐Jenkins (ORCID: https://orcid.org/0000-0002-6015-762X)
- Minhui Ouyang (ORCID: https://orcid.org/0000-0001-8013-2553)
- Erik Lee (ORCID: https://orcid.org/0000-0001-9236-5100)
- Thomas Pengo (ORCID: https://orcid.org/0000-0002-9632-918X)
- Jens T. Rosenberg (ORCID: https://orcid.org/0000-0001-5957-0313)
- Cécile Madjar (ORCID: https://orcid.org/0000-0003-1108-031X)
- Taylor Salo (ORCID: https://orcid.org/0000-0001-9813-3167)
- Jessica L. Wisnowski (ORCID: https://orcid.org/0000-0002-4039-8362)
- Alexander J. Dufford (ORCID: https://orcid.org/0000-0002-8846-5624)
- Allen T. Newton (ORCID: https://orcid.org/0000-0001-6539-8783)
- Jean A. Tkach (ORCID: https://orcid.org/0000-0003-4593-7481)
- Vidya Rajagopalan (ORCID: https://orcid.org/0000-0002-7871-6768)
- Anders M. Dale (ORCID: https://orcid.org/0000-0002-6126-2966)
- M. Dylan Tisdall (ORCID: https://orcid.org/0000-0002-0454-3112)
- Elizabeth S. Norton (ORCID: https://orcid.org/0000-0002-4023-8051)
- Gizeaddis Simegn
- Xu Li (ORCID: https://orcid.org/0000-0002-4350-3375)
- Hao Huang (ORCID: https://orcid.org/0000-0001-5174-0920)
- Yulin V. Chang (ORCID: https://orcid.org/0000-0003-2714-2634)
- Guillaume Gilbert (ORCID: https://orcid.org/0000-0002-9960-1062)
- Samir Das
- Maarten J. Versluis (ORCID: https://orcid.org/0000-0003-3601-0377)
- Alice M. Graham (ORCID: https://orcid.org/0000-0002-1416-1193)
- Suchandrima Banerjee
- Maren Macgregor-Hannah
- Laetitia Fesselier
- Theodore D Satterthwaite
- Barry J Tikalsky
- Regis Ongaro-Carcy
- Xavier Lecour-Bourcher
- W. Kyle Simmons
- Pierre Rioux
- Kathryn L. Humphreys
- B. Caron
- Samuel Carpenter (ORCID: https://orcid.org/0000-0002-2196-6205)
Institutions
- Northwestern University (US)
- Cedars-Sinai Medical Center (US)
- Cincinnati Children's Hospital Medical Center (US)
- George Washington University Hospital (US)
- Boston Children's Hospital (US)
- Montreal Neurological Institute and Hospital (CA)
- Kennedy Krieger Institute (US)
- Arkansas Children's Hospital (US)
- University of Minnesota (US)
- Pennsylvania State University (US)
- Philips (Finland) (FI)
- Mind Research Network (US)
- Children's Hospital of Philadelphia (US)
- Children's Hospital of Los Angeles (US)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- Oregon Health & Science University (US)
- University of Alabama (US)
- General Electric (Spain) (ES)
- George Washington University (US)
- Vanderbilt University (US)
- Washington University in St. Louis (US)
- University of Minnesota System (US)
- University of Florida (US)
- University of California San Diego (US)
- University of Oxford (GB)
- National Institute of Biomedical Imaging and Bioengineering (US)
- Wellcome Centre for Integrative Neuroimaging (GB)
- Mallinckrodt (United States) (US)
- Virginia Tech - Wake Forest University School of Biomedical Engineering & Sciences (US)
- CARE Canada (CA)
- Medical Solutions (GB)
- Philips (United States) (US)
- Lifespan (US)
- Resonance Research (United States) (US)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Maryland, College Park (US)
- Oklahoma State University Center for Health Sciences (US)
- University of Pennsylvania (US)
- University of Arkansas for Medical Sciences (US)
- Virginia Tech (US)
- Vanderbilt University Medical Center (US)
- Stanford University (US)
- University of Lausanne (CH)
Publication Details
- Journal
- Developmental Cognitive Neuroscience
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.dcn.2024.101452
- Citations
- 20
- Primary Topic
- Advanced MRI Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 8.09
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute on Drug Abuse
- National Cancer Institute
- National Institute of Biomedical Imaging and Bioengineering