Spatiotemporal EP4–fibulin-1 expression is associated with vascular intimal hyperplasia
EP4 was upregulated in VSMCs of proliferative IH, and EP4 signalling promoted IH, at least in part through fibulin-1. An EP4 antagonist might be considered as a therapeutic strategy for IH.
Authors
- Masahiko Kuroda (ORCID: https://orcid.org/0000-0001-7052-4289)
- Shigekuni Okumura
- Utako Yokoyama (ORCID: https://orcid.org/0000-0003-1803-0155)
- Shin‐ichiro Ohno (ORCID: https://orcid.org/0000-0003-1064-4750)
- Marion A. Cooley (ORCID: https://orcid.org/0000-0002-4286-745X)
- Shota Tanifuji
- Yuko Hidaka (ORCID: https://orcid.org/0000-0002-4890-6317)
- Takako Sasaki (ORCID: https://orcid.org/0000-0003-0514-9931)
- Mari Kaneko (ORCID: https://orcid.org/0000-0001-6122-6191)
- H. Inoue (ORCID: https://orcid.org/0000-0002-2278-5617)
- Takaya Abe (ORCID: https://orcid.org/0000-0001-5885-4875)
- Tadashi Yokosuka (ORCID: https://orcid.org/0000-0002-3914-3995)
- Richard Breyer (ORCID: https://orcid.org/0000-0001-5828-4403)
- Yuko Kato (ORCID: https://orcid.org/0000-0002-1535-1925)
- Hiroshi Homma (ORCID: https://orcid.org/0000-0002-0886-9435)
- Hitoshi Nishijima (ORCID: https://orcid.org/0000-0002-7328-6359)
- Sayuki Oka (ORCID: https://orcid.org/0009-0002-4730-9446)
Institutions
- Tokyo Medical University (JP)
- Oita University (JP)
- Augusta University (US)
- Augusta University Health (US)
- Oita Medical Center (JP)
- RIKEN Center for Biosystems Dynamics Research (JP)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Cardiovascular Research
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1093/cvr/cvae211
- Citations
- 5
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 2.24