Improved contingent screening strategy increased trisomy 21 detection rate in the second trimester
Utilizing threshold values of AFP, free β-hCG, and uE3 to trigger further non-invasive prenatal screening may increase trisomy 21 detection in pregnancies deemed low risk in the second trimester while reducing the overall costs of screening strategies.
Authors
- Shanling Liu (ORCID: https://orcid.org/0000-0001-8788-7991)
- Bin He (ORCID: https://orcid.org/0000-0002-3072-6238)
- Ting Hu (ORCID: https://orcid.org/0000-0002-4642-3848)
- Fene Zou
- Daiwen Han
- Kai Zhao
- Lixing Yuan (ORCID: https://orcid.org/0000-0002-4435-3225)
- Ling Pang
- Wei Luo (ORCID: https://orcid.org/0000-0002-8465-5607)
- Jun Tang (ORCID: https://orcid.org/0000-0001-6253-9704)
Institutions
- Sichuan University (CN)
- West China Medical Center of Sichuan University (CN)
- West China Second University Hospital of Sichuan University (CN)
Publication Details
- Journal
- Archives of Gynecology and Obstetrics
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1007/s00404-024-07743-4
- Primary Topic
- Prenatal Screening and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan Province Science and Technology Support Program
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities