UMOD Genotype and Determinants of Urinary Uromodulin in African Populations
We evidenced ethnic differences in clinical and genetic determinants of uUMOD levels, in particular an interaction of ethnicity on the relationship between CKD-risk SNPs and uUMOD. These differences should be considered when analyzing the role of uromodulin in kidney function, interpreting genome-wide association studies (GWAS), and precision medicine recommendations.
Authors
- Ruan Kruger (ORCID: https://orcid.org/0000-0001-7680-2032)
- Patrick Hofmann (ORCID: https://orcid.org/0000-0002-4586-641X)
- Olivier Devuyst (ORCID: https://orcid.org/0000-0003-3744-4767)
- John Andrew Sayer (ORCID: https://orcid.org/0000-0003-1881-3782)
- Ian Wilson (ORCID: https://orcid.org/0000-0001-6893-2873)
- Aletta Elisabeth Schutte (ORCID: https://orcid.org/0000-0001-9217-4937)
- Michél Strauss‐Kruger (ORCID: https://orcid.org/0000-0003-0619-4654)
- Eric Olinger (ORCID: https://orcid.org/0000-0003-1178-7980)
- Catharina M. C. Mels (ORCID: https://orcid.org/0000-0003-0138-3341)
- Lebo F. Gafane‐Matemane (ORCID: https://orcid.org/0000-0003-4596-7218)
- Cristian Ricci (ORCID: https://orcid.org/0000-0003-4113-8682)
Institutions
- Cliniques Universitaires Saint-Luc (BE)
- University of the Witwatersrand (ZA)
- University of Zurich (CH)
- North-West University (ZA)
- UNSW Sydney (AU)
- The George Institute for Global Health (AU)
- Newcastle University (GB)
Publication Details
- Journal
- Kidney International Reports
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.ekir.2024.09.015
- Citations
- 4
- Primary Topic
- Pediatric Urology and Nephrology Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.44
Funders
- National Science Foundation
- Pfizer
- GlaxoSmithKline
- LifeArc
- Government of the United Kingdom
- Kidney Research UK
- European Commission
- National Research Foundation
- South African Medical Research Council
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Northern Counties Kidney Research Fund
- Medical Research Council