Simulated bupivacaine pharmacokinetics after labor epidural analgesia followed by transversus abdominis plane block with liposomal bupivacaine for intrapartum cesarean delivery
Across 6 different simulations of TAP blocks for intrapartum CD analgesia, LEA with bupivacaine (with or without boluses for extension and including a conservative modeling of lidocaine without epinephrine), followed by TAP block with LB and/or bupivacaine hydrochloride 0, 1, or 2 h after CD, is unlikely to result in bupivacaine plasma concentrations reaching local anesthetic systemic toxicity thresholds in healthy patients.
Authors
- Ruth Landau (ORCID: https://orcid.org/0000-0002-3737-7536)
- Jia Song (ORCID: https://orcid.org/0000-0002-9484-6669)
- Daniel Katz (ORCID: https://orcid.org/0000-0003-4600-2629)
- Roy Winston (ORCID: https://orcid.org/0000-0003-2193-3136)
- Matthew Carangelo
- Timothy Bergsma
Institutions
- National Court Reporters Association (US)
- Pacira (United States) (US)
- Columbia University (US)
- University of Tampa (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Journal of Clinical Anesthesia
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.jclinane.2024.111589
- Citations
- 3
- Primary Topic
- Anesthesia and Pain Management
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Pacira Pharmaceuticals