A green, cheap and robust method for selective hydrogenation of nitroarenes

A commercially available nickel was utilized as an effective catalyst for the exclusive hydrogenation of nitroarenes to primary anilines in gram-scale without additional column chromatographic purification. This novel synthetic hydrogenation strategy features wide substrate scope, mild conditions and operational simplicity in aqueous media at room temperature . Further transformations resulted in the delivery of important amine-containing drugs and pharmaceutical intermediates. A commercially available nickel catalyst was utilized for the hydrogenation of nitroaromatics to primary amines in high yields and purity without additional column chromatography. This novel synthetic protocol operates effectively in aqueous media at room temperature, eliminating the need for organic solvents. Further transformations resulted in the delivery of important amine-containing drugs and pharmaceutical intermediates. • Use of commercially available catalyst. • Primary amines were produced in high yields and purity without the need for additional column chromatography. • Operate effectively in aqueous media at room temperature, eliminating the need for organic solvents. • Obtain pure halogenated anilines.