The role of CD24hiCD27+ regulatory B cells in human chronic rhinosinusitis with/without nasal polyps
This study is the first to reveal differences in both the quantity and IL-10 secretion of B10 cells in patients with eCRSwNP and neCRSwNP. These variations were strongly negatively associated with eosinophils in nasal polyps and peripheral blood. IL-10<sup>+</sup>B10 cells may play a key role in the pathological mechanisms of CRS, particularly the recurrence of eCRSwNP.
Authors
- R. Zhang
- Kebin Liu (ORCID: https://orcid.org/0000-0003-1965-7240)
- Chunli Zhao (ORCID: https://orcid.org/0000-0002-4059-876X)
- Hao Tian
- Xia Jiao (ORCID: https://orcid.org/0000-0003-4711-2950)
- Youxiang Ma
- Shusheng Gong (ORCID: https://orcid.org/0000-0002-1429-2118)
- Shiyu Tian
- Weiwei Wang (ORCID: https://orcid.org/0000-0003-2678-1581)
Institutions
- Capital Medical University (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Immunobiology
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1016/j.imbio.2024.152854
- Citations
- 1
- Primary Topic
- Sinusitis and nasal conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- National Natural Science Foundation of China