Estimation of vaccine effectiveness against SARS-CoV-2-associated hospitalization using sentinel surveillance in South Africa
The BNT162b2 vaccine was effective against SARS-CoV-2-associated hospitalization during the Delta period for adults aged ≥18 years, ≥60 years and those HIV-uninfected. VE for Ad26.COV2.S was inconclusive, potentially due to limited sample size or residual confounding. These findings highlight the utility of sentinel surveillance for estimating VE.
Authors
- Aaron M. Samuels (ORCID: https://orcid.org/0000-0002-8355-8186)
- Perrine Marcenac (ORCID: https://orcid.org/0000-0002-6726-6124)
- Mvuyo Makhasi (ORCID: https://orcid.org/0000-0002-7647-9463)
- Halima Dawood (ORCID: https://orcid.org/0000-0001-8180-6791)
- Michelle J. Groome (ORCID: https://orcid.org/0000-0001-5893-3725)
- Nicole Wolter (ORCID: https://orcid.org/0000-0002-9526-0133)
- Leora R. Feldstein
- Anne von Gottberg (ORCID: https://orcid.org/0000-0002-0243-7455)
- Mignon du Plessis (ORCID: https://orcid.org/0000-0001-9186-0679)
- Jeremy Nel
- Kathryn E. Lafond (ORCID: https://orcid.org/0000-0001-5018-9591)
- Sibongile Walaza (ORCID: https://orcid.org/0000-0001-7588-2480)
- Nicola Chiwandire (ORCID: https://orcid.org/0000-0002-4384-636X)
- Ebrahim Variava (ORCID: https://orcid.org/0000-0003-2888-789X)
- Fahima Moosa (ORCID: https://orcid.org/0000-0003-0281-3649)
- Cheryl Cohen (ORCID: https://orcid.org/0000-0003-0376-2302)
Institutions
- National Health Laboratory Service (ZA)
- Centers for Disease Control and Prevention (US)
- National Center for Immunization and Respiratory Diseases (US)
- University of the Witwatersrand (ZA)
- Kalafong Hospital (ZA)
- Grey's Hospital (ZA)
- National Institute for Communicable Diseases
Publication Details
- Journal
- International Journal of Epidemiology
- Published
- 2024-08-14
- DOI
- https://doi.org/10.1093/ije/dyae116
- Citations
- 3
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- Wellcome Trust