<i>In silico</i> and <i>in vivo</i> verification of the mechanism of formononetin in treating hepatocellular carcinoma
Formononetin demonstrates dose-dependent regulatory effects on multiple targets, biological processes and signalling pathways in HCC. The compound can mitigate HCC by enhancing PI3K/AKT-mediated apoptosis of tumour cells.
Authors
- Shiping Hu (ORCID: https://orcid.org/0000-0003-3289-614X)
- Guiping Ma (ORCID: https://orcid.org/0000-0002-4800-2414)
- Li Feng (ORCID: https://orcid.org/0000-0002-9162-8922)
- Bowen Liu (ORCID: https://orcid.org/0009-0009-9448-7588)
- Wenlin Chen (ORCID: https://orcid.org/0000-0003-4687-2384)
- Xiaobin Li (ORCID: https://orcid.org/0000-0002-3775-7694)
- Xu Pang
- Yichi Zhou
- Yun Ran (ORCID: https://orcid.org/0009-0009-2478-9994)
Institutions
- Beijing University of Chinese Medicine (CN)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1080/07853890.2024.2404550
- Citations
- 5
- Primary Topic
- Phytoestrogen effects and research
- Type
- article
- Field-Weighted Citation Impact
- 2.12
Funders
- National Natural Science Foundation of China