CircMAPK1 induces cell pyroptosis in sepsis-induced lung injury by mediating KDM2B mRNA decay to epigenetically regulate WNK1
CircMAPK1 exacerbates sepsis-induced lung injury by destabilizing KDM2B mRNA to suppress WNK1 expression, thus facilitating NLRP3-driven macrophage pyroptosis.
Authors
- Li Zhao (ORCID: https://orcid.org/0000-0003-2590-2417)
- Xiaoran Liu (ORCID: https://orcid.org/0000-0002-7245-8702)
- Hanjing Lu
- Chujun Ruan
- Ke Qiao
- Longhui Hu
- Min Li (ORCID: https://orcid.org/0000-0001-8786-5629)
Institutions
- Hainan General Hospital (CN)
- Hainan Medical College Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s10020-024-00932-6
- Citations
- 5
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.17
Funders
- National Natural Science Foundation of China