Pharmacological inhibition of the CB1 cannabinoid receptor restores abnormal brain mitochondrial CB1 receptor expression and rescues bioenergetic and cognitive defects in a female mouse model of Rett syndrome
The present data identify mtCB1R overexpression as a novel molecular alteration in the RTT mouse brain that may underlie defective brain mitochondrial bioenergetics and cognitive dysfunction.
Authors
- Daniela Valenti (ORCID: https://orcid.org/0000-0001-7638-8724)
- Domenico De Rasmo (ORCID: https://orcid.org/0000-0002-3917-2411)
- Livia Cosentino (ORCID: https://orcid.org/0000-0001-8925-3829)
- Chiara Urbinati (ORCID: https://orcid.org/0000-0001-6264-0247)
- Rosa Anna Vacca (ORCID: https://orcid.org/0000-0003-2438-6449)
- Fabio Di Domenico (ORCID: https://orcid.org/0000-0002-2013-209X)
- Bianca De Filippis (ORCID: https://orcid.org/0000-0002-6508-1206)
- Chiara Lanzillotta (ORCID: https://orcid.org/0000-0002-6883-7806)
- Fabiana Piscitelli (ORCID: https://orcid.org/0000-0001-9343-4622)
- Anna Signorile (ORCID: https://orcid.org/0000-0001-9045-891X)
- Tiziana Bisogno (ORCID: https://orcid.org/0000-0002-5567-2272)
- Donatella Pietraforte (ORCID: https://orcid.org/0000-0001-6370-912X)
- Maria Cristina Quattrini (ORCID: https://orcid.org/0000-0001-6631-115X)
- Mattia Pellas
- Magdalena Kostrzewa (ORCID: https://orcid.org/0000-0002-3395-5191)
Institutions
- National Institute of Health (AM)
- Istituto di Farmacologia Traslazionale (IT)
- Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IT)
- National Research Council (IT)
- University of Bari Aldo Moro (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- Molecular Autism
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1186/s13229-024-00617-1
- Citations
- 10
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 5.50
Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Ministero dell'Università e della Ricerca