Imperatorin ameliorates ferroptotic cell death, inflammation, and renal fibrosis in a unilateral ureteral obstruction mouse model
Our finding demonstrated for the first time, that imperatorin treatment holds therapeutic potential in a UUO mouse model of CKD and inhibits the erastin-induced oxidative stress, ferroptosis, and subsequent lipid peroxidation in vitro. This highlights the potential of imperatorin as a future therapeutic target for ferroptosis to improve the progression of CKD.
Authors
- Yen‐Hao Su (ORCID: https://orcid.org/0000-0001-8288-3772)
- Cheng‐Tien Wu (ORCID: https://orcid.org/0000-0002-7240-8465)
- Kuan‐I Lee (ORCID: https://orcid.org/0000-0001-8248-7761)
- Jr-Di Yang
- Shing‐Hwa Liu (ORCID: https://orcid.org/0000-0002-9976-1197)
- C. M. Chen
- Pei Wang (ORCID: https://orcid.org/0000-0002-6890-6453)
- Ssu Chia Lin
- Pei Yu Weng
- Siao Syun Guan
- Po Lin Liao
- Haw Ling Chuang
- Yu Syuan Chen
- Huey Liang Kuo
- Chun Fa Huang
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Taiwan University (TW)
- China Medical University (TW)
- Atomic Energy Council (TW)
- Taipei Medical University Hospital (TW)
- National Yang Ming University Hospital (TW)
- Taipei Tzu Chi Hospital (TW)
- China Medical University Hospital (TW)
- National Taiwan University Hospital (TW)
- Institute of Nuclear Energy Research (TW)
- Buddhist Tzu Chi Medical Foundation (US)
- Taipei Medical University-Shuang Ho Hospital (TW)
- Taipei Medical University (TW)
Publication Details
- Journal
- Phytomedicine
- Published
- 2024-09-16
- DOI
- https://doi.org/10.1016/j.phymed.2024.156066
- Citations
- 8
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Yang Ming University
- China Medical University, Taiwan
- Dalin Tzu Chi Hospital