04146 Enhanced ETB-dependent contraction mediates increased ET-1 responses in mesenteric arteries in the AIP mouse model

61.1% down expressed) in a human liver cancer cell line (GSE168473).Analyzing Free Wilson's equations to find possible drugs to replace those insecure for AIP patients, some derivatives of Thiofeno [3,2]pyrimidine would represent therapeutic alternatives to Efavirenz.These derivatives would have a differential action as substrates/inhibitors of ABCB1 transporter and CYP.Associations between non-wild type variants of ABCB1 and ABCG2, drugs contraindicated in AIP and a phenotype of toxicity or alteration of metabolism were also found: rs1045642, rs1128503 and rs1128503 for ABCB1 (13, 2, and 2 xenobiotics, respectively); and rs2231137 and rs2231142 for ABCG2 (2 and 10 xenobiotics, respectively).In conclusion, it was observed that contraindicated drugs for AIP patients are associated with toxicity and a differential metabolism in the presence of the studied variants.In turn, these drugs alter the gene expression of drug metabolizing and transporting systems.Bioinformatics tools are a valuable complement for experimental findings and for exploring new approaches and would be of relevance in personalized medicine and pharmacogenetics, a topic of upmost relevance in the pathophysiology of Hepatic Porphyrias.