Liposome‐encapsulated hemoglobin rescues hemorrhagic shock heart through anti‐ischemic and anti‐arrhythmogenic effects on myocardium in repetitive 65% bleeding rat model
Acute lethal hemorrhage causes myocardial ischemia with hypoxia and arrhythmias, which may be induced by impaired APDd and myocardial damage, reflected in the increased levels of HIF1-alpha and TnI. HbVs could be useful for resuscitation and may help save patients with injuries such as gunshot wounds.
Authors
- Nobuyuki Masaki (ORCID: https://orcid.org/0000-0002-4426-3692)
- Takeshi Adachi (ORCID: https://orcid.org/0000-0002-9830-6627)
- Yuko Higashimura
- Manabu Kinoshita (ORCID: https://orcid.org/0000-0002-2750-3084)
- Hiromi Sakai (ORCID: https://orcid.org/0000-0002-0681-3032)
- Bonpei Takase (ORCID: https://orcid.org/0000-0002-7889-6260)
Institutions
- Heart Life Hospital (JP)
- National Defense Medical College (JP)
- Nara Medical University (JP)
Publication Details
- Journal
- Artificial Organs
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1111/aor.14858
- Citations
- 2
- Primary Topic
- Cardiac Arrest and Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 1.38