Investigating the active components and mechanistic effects of Forsythia suspensa Leaf against RSV via the PI3K/Akt-NLRP3 pathway
Phillyrin, the active component in FSL, can not only directly inhibit the replication of RSV, but also effectively control the inflammatory reaction caused by RSV infection and improve lung injury, which is expected to become a potential drug against RSV pneumonia.
Authors
- Tiefeng Sun (ORCID: https://orcid.org/0009-0005-6384-6016)
- Lin Wang (ORCID: https://orcid.org/0000-0001-7383-934X)
- Ping Wang (ORCID: https://orcid.org/0000-0001-7517-8688)
- X. J. Wang
- Na Li (ORCID: https://orcid.org/0000-0002-8754-2851)
- Dong Li (ORCID: https://orcid.org/0000-0002-8581-8658)
- Ru Zhang (ORCID: https://orcid.org/0000-0001-8744-4525)
- Guixia Liu (ORCID: https://orcid.org/0000-0001-9648-844X)
- Weilian Ren
- Haitao Du
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Jinan Maternity And Care Hospital (CN)
- Fourth People’s Hospital of Jinan (CN)
- Weifang People's Hospital (CN)
- Zoucheng People's Hospital (CN)
- Qingdao Center of Resource Chemistry and New Materials (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-21
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38285
- Citations
- 8
- Primary Topic
- Plant Virus Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.80