IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice
This study elucidates the pivotal role of plasmacytoid dendritic cells (pDCs) in systemic sclerosis (SSc). This study identified the key regulatory gene involved in systemic sclerosis (SSc) as IFIT3. This study has found that IFIT3 functions as an upstream regulatory factor, activating TBK1. This study provides Evidence of the regulatory effects of the IFIT3/TBK1 pathway on plasmacytoid dendritic cells (pDCs). This study validated the therapeutic potential using the IFIT3<sup>-/-</sup> mouse model.
Authors
- Dan Feng (ORCID: https://orcid.org/0000-0002-0311-8990)
- Wanhong Xing (ORCID: https://orcid.org/0009-0001-8718-3975)
- Yiheng Zhao
- Jun Wang (ORCID: https://orcid.org/0000-0001-9264-306X)
- Yi Liu (ORCID: https://orcid.org/0000-0003-1513-8638)
- Xiangyang Huang (ORCID: https://orcid.org/0000-0003-3255-5775)
- Xia Rong
Institutions
- MGH Institute of Health Professions (US)
- West China Medical Center of Sichuan University (CN)
- The Sixth People's Hospital of Shenyang (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/ctm2.1800
- Citations
- 4
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.70
Funders
- National Natural Science Foundation of China