Selective modulation of epileptic tissue by an adenosine A<sub>3</sub> receptor‐activating drug
We identified a drug that activates A<sub>3</sub>R and has selective actions on epileptic hippocampal tissue. This underscores A<sub>3</sub>R as a promising target for the development of antiseizure medications.
Authors
- Gabriele Ruffolo (ORCID: https://orcid.org/0000-0002-6554-5496)
- Eleonora Aronica (ORCID: https://orcid.org/0000-0002-3542-3770)
- Sara Xapelli (ORCID: https://orcid.org/0000-0001-6854-2509)
- Eleonora Palma (ORCID: https://orcid.org/0000-0001-6026-927X)
- Anwesha Ghosh (ORCID: https://orcid.org/0000-0003-1765-9832)
- Ana M. Sebastião (ORCID: https://orcid.org/0000-0001-9030-6115)
- Dilip K. Tosh (ORCID: https://orcid.org/0000-0003-0932-4143)
- Maria José Diógenes (ORCID: https://orcid.org/0000-0001-5486-6246)
- Sandra Henriques Vaz (ORCID: https://orcid.org/0000-0003-4258-9397)
- Alexandre Rainha Campos (ORCID: https://orcid.org/0000-0003-4781-4717)
- Cátia Domingos
- Joaquim A. Ribeiro (ORCID: https://orcid.org/0000-0002-9330-3507)
- Veronica Alfano
- Leonor Ribeiro‐Rodrigues
- Carla C Bentes (ORCID: https://orcid.org/0000-0003-2399-7678)
- Tatiana P. Morais (ORCID: https://orcid.org/0000-0002-7486-9409)
- Cláudia A. Valente (ORCID: https://orcid.org/0000-0001-5405-3130)
- Diogo M. Rombo (ORCID: https://orcid.org/0000-0002-9922-7381)
- Kenneth A. Jacobson (ORCID: https://orcid.org/0000-0001-8104-1493)
- Nádia Rei (ORCID: https://orcid.org/0000-0003-0131-0126)
- Beatriz Bordadágua
Institutions
- National Institutes of Health (US)
- University of Lisbon (PT)
- University of Malta (MT)
- Universidade Politécnica de Lisboa (PT)
- Heidelberg University (DE)
- National Institute of Diabetes and Digestive and Kidney Diseases (US)
- Amsterdam Neuroscience (NL)
- Amsterdam University Medical Centers (NL)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Stichting Epilepsie Instellingen Nederland (NL)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- Heidelberg Institute for Theoretical Studies (DE)
- Cardiff University (GB)
- Sapienza University of Rome (IT)
- University of Amsterdam (NL)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2024-09-19
- DOI
- https://doi.org/10.1111/bph.17319
- Citations
- 5
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Ministero della Salute
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Sapienza Università di Roma
- International Society for Neurochemistry
- Horizon 2020 Framework Programme
- Fundação para a Ciência e a Tecnologia
- National Institute of Diabetes and Digestive and Kidney Diseases