Bacterial Epidemiology and Antimicrobial Resistance Profiles of Bloodstream Infections Caused by Negative Bacteria in Children’s: A Multicenter Study in China (2016–2022)
The detection rate of gram-negative pathogens showed an increasing trend among the bloodstream infection. The detection rate of CRKPN assumed a downward trend in 2018. There are differences types of pathogens between the neonatal group and the pediatric group, The detection rate of CRKPN in the neonate group was significantly higher than pediatric group. The first average detection rates for carbapenem resistance, extended-spectrum cephalosporin resistance, and fluoroquinolone resistance were obtained for <i>A. baumannii, K. pneumoniae</i>, and <i>Escherichia coli</i>, respectively. Those data showed a high level of antimicrobial resistance, which has posed an urgent threat to Children's health, suggested that effective monitoring of antimicrobial resistance and antimicrobial stewardship among children in China are required.
Authors
- Wei Gao (ORCID: https://orcid.org/0000-0001-8834-8973)
- Xuejun Chen (ORCID: https://orcid.org/0000-0001-9192-0440)
- Hong Zhang (ORCID: https://orcid.org/0000-0002-0886-9531)
- Ningning Wu
- Shifu Wang (ORCID: https://orcid.org/0000-0002-2131-9518)
- Jikui Deng (ORCID: https://orcid.org/0000-0002-0040-1491)
- Chunmei Jing (ORCID: https://orcid.org/0009-0005-9930-3582)
- Yinghu Chen (ORCID: https://orcid.org/0000-0001-8022-9478)
- Hongmei Xu (ORCID: https://orcid.org/0000-0002-8650-8694)
- Chunzhen Hua
- Chuanqing Wang (ORCID: https://orcid.org/0000-0002-0158-9094)
- Hongmei Wang (ORCID: https://orcid.org/0000-0002-4219-4531)
- Hui Yu (ORCID: https://orcid.org/0000-0002-6559-6111)
- Ting Zhang
- Jianhua Hao (ORCID: https://orcid.org/0009-0007-0032-7221)
- Qing Cao
- Huiling Deng (ORCID: https://orcid.org/0009-0003-1850-2690)
- Sancheng Cao
- Yiping Chen
Institutions
- Wenzhou Medical University (CN)
- Shanghai Children's Medical Center (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
- Children's Hospital of Zhejiang University (CN)
- Kaifeng City Children's Hospital (CN)
- Xi’an Children’s Hospital (CN)
- Shenzhen Children's Hospital (CN)
- Children's Hospital of Fudan University (CN)
- Shanghai Children's Hospital (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Qilu Hospital of Shandong University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Infection and Drug Resistance
- Published
- 2024-09-01
- DOI
- https://doi.org/10.2147/idr.s473227
- Citations
- 3
- Primary Topic
- Bacterial Identification and Susceptibility Testing
- Type
- article
- Field-Weighted Citation Impact
- 1.14
Funders
- Centre Scientifique et Technique du Bâtiment