Altered immune cell in human severe acute pancreatitis revealed by single-cell RNA sequencing
This study reveals monocytes' crucial role in SAP initiation and progression, characterized by distinct pro-inflammatory features intricately linked to AP severity. A monocyte subpopulation with elevated <i>PPBP</i> and <i>CCL3</i> levels emerges as a potential biomarker and therapeutic target.
Authors
- Zhaohui Du (ORCID: https://orcid.org/0000-0002-6736-4373)
- Junjie Tao (ORCID: https://orcid.org/0000-0002-1002-6496)
- Zhiheng Wu
- Shijie Wang
- Lei Li (ORCID: https://orcid.org/0000-0001-5304-8380)
- Zhipeng Xu (ORCID: https://orcid.org/0000-0003-1734-2077)
- Chuanming Zheng
- A Xu (ORCID: https://orcid.org/0000-0003-1470-1978)
- Zheyi Wu
- Pengzhen Liang
- Zhenjie Wang (ORCID: https://orcid.org/0000-0002-1890-1806)
- Chengpu Zhao
Institutions
- Bengbu Medical College (CN)
- Anhui Medical University (CN)
- Huangshan University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1354926
- Citations
- 1
- Primary Topic
- Pancreatitis Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.57
Funders
- Anhui Provincial Department of Education
- University Natural Science Research Project of Anhui Province