1,25-dihydroxyvitamin-D3 distinctly impacts the paracrine and cell-to-cell contact interactions between hPDL-MSCs and CD4+ T lymphocytes
These data assume that 1,25(OH)<sub>2</sub>D<sub>3</sub> differently affects CD4<sup>+</sup> T lymphocytes via the paracrine and direct cell-to-cell contact mechanisms of hPDL-MSCs, showing anti- or pro-inflammatory effects depending on the co-culture model type. The local cytokine microenvironment seems to be involved in fine-tuning these effects. Future studies should consider this double-edged observation by executing different co-culture models in parallel.
Authors
- Christian Behm (ORCID: https://orcid.org/0000-0002-3065-3200)
- Xiaohui Rausch‐Fan (ORCID: https://orcid.org/0000-0002-8010-1914)
- Oleh Andrukhov (ORCID: https://orcid.org/0000-0002-0485-2142)
- Oliwia Miłek (ORCID: https://orcid.org/0000-0001-8170-8155)
- Katharina Schwarz (ORCID: https://orcid.org/0000-0002-6649-116X)
- Andreas Moritz (ORCID: https://orcid.org/0000-0001-7898-7368)
Institutions
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1448597
- Citations
- 2
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 0.88
Funders
- Austrian Science Fund