Cytosolic nucleic acid sensors and interferon beta-1 activation drive radiation-induced anti-tumour immune effects in human pancreatic cancer cells
Our findings provide a rationale for combinatorial radiation-immunomodulatory treatment approaches in PDAC using conventional photon-based or proton beam radiotherapy.
Authors
- Filip Horvat (ORCID: https://orcid.org/0000-0002-1896-7645)
- Sandra Barna (ORCID: https://orcid.org/0000-0001-5455-9481)
- Bernhard Kratzer (ORCID: https://orcid.org/0000-0003-1091-4327)
- Vedran Franke (ORCID: https://orcid.org/0000-0003-3606-6792)
- Winfried Franz Pickl (ORCID: https://orcid.org/0000-0003-0430-4952)
- Sylvia Gruber (ORCID: https://orcid.org/0000-0001-5280-1676)
- Johannes Benedum (ORCID: https://orcid.org/0000-0003-4475-7577)
- Dietmar Georg (ORCID: https://orcid.org/0000-0002-8327-3877)
- Joachim Widder (ORCID: https://orcid.org/0000-0002-9972-6690)
- Dea Slade (ORCID: https://orcid.org/0000-0002-0052-5910)
- Lisa-Marie Appel (ORCID: https://orcid.org/0000-0002-6769-0777)
- Anna M. Rohrer
- Lena Walch
- Altuna Akalin (ORCID: https://orcid.org/0000-0002-0468-0117)
- Katharina Stasny
- Ana Beatriz Toledo Dias (ORCID: https://orcid.org/0000-0001-5496-7573)
- Ava Kleinwächter
- Alexandra Kneringer
- Andreas Postl
- K. Popova
Institutions
- Max Delbrück Center (DE)
- Max Perutz Labs (AT)
- Comprehensive Cancer Center Vienna (AT)
- Vienna Biocenter (AT)
- Karl Landsteiner University of Health Sciences (AT)
- MedAustron (AT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3389/fimmu.2024.1286942
- Citations
- 6
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.44
Funders
- Austrian Science Fund
- Universität Wien
- Medizinische Universität Wien