Decreased ATF5 level contributes to improved mitochondrial function in oocytes exposed to vitrification stress
Our findings indicate that mtUPR was initiated in response to vitrification stimuli, and downregulated ATF5 level to a homeostatic state contributes to improved mitochondrial function in oocytes exposed to vitrification stress. Our results highlight the crucial role of ATF5 in the regulation of mitochondrial function in vitrified oocytes through mediating mtUPR.
Authors
- Jiachen Bai
- Yunpeng Hou (ORCID: https://orcid.org/0000-0002-6807-8336)
- Yuwen Luo
- Xiangwei Fu (ORCID: https://orcid.org/0000-0003-1638-6852)
- Guizhen Zhou
- Yixiao Zhu
- Jun Li (ORCID: https://orcid.org/0000-0002-2121-3393)
- Lv Zheng
- Aiju Liu (ORCID: https://orcid.org/0000-0001-9939-3374)
- Hongyu Liu (ORCID: https://orcid.org/0009-0002-6718-7976)
Institutions
- Hebei Medical University (CN)
- First Affiliated Hospital of Hebei Medical University (CN)
- China Agricultural University (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.3389/fcell.2024.1431683
- Citations
- 7
- Primary Topic
- Reproductive Biology and Fertility
- Type
- article
- Field-Weighted Citation Impact
- 3.80
Funders
- Pohang University of Science and Technology
- Natural Science Foundation of Hebei Province
- National Key Research and Development Program of China