Single-atom materials boosting wearable orthogonal uric acid detection
Abstract Uric acid (UA) is a vital biomarker for the diagnosis and management of various health conditions, including cardiovascular diseases, gout, kidney disorders, metabolic syndrome, and wound healing. Despite significant advances in wearable sensor technology, challenges persist in developing wearable sensors that are capable of maintaining high sensitivity, selectivity, and stability. In this study, we present an epidermal sensing platform enhanced with single-atom materials (SAMs) designed for flexible and orthogonal electrochemical detection of UA. We designed and synthesized an SAM with Fe-N 5 active sites to boost the electrochemical sensing signals, integrating it with laser-engraved graphene (LEG) to fabricate a wearable SAM-based UA patch sensor. This design provides superior UA detection performance compared to sensors based on conventional nanomaterials. In addition, we enhanced the detection accuracy and range by using an orthogonal approach that combines direct oxidation through differential pulse voltammetry (DPV) along with parallel biocatalytic amperometric detection. The resulting SAM-based UA orthogonal sensor patch demonstrated exceptional performance in wearable applications through tests measuring sweat UA levels in subjects before and after consuming a purine-rich diet. Graphical Abstract
Authors
- Xiaoqing Pan (ORCID: https://orcid.org/0000-0002-0965-8568)
- Yuehe Lin (ORCID: https://orcid.org/0000-0003-3791-7587)
- Jiachi Zhou (ORCID: https://orcid.org/0000-0001-9385-7174)
- Wenjie Zang (ORCID: https://orcid.org/0000-0003-0604-9131)
- Sunjae Kim (ORCID: https://orcid.org/0000-0002-0518-8116)
- Zhaoyuan Lyu (ORCID: https://orcid.org/0000-0003-0888-8297)
- Shichao Ding (ORCID: https://orcid.org/0000-0003-3795-306X)
- Lingzhe Fang (ORCID: https://orcid.org/0000-0001-9243-7741)
- Dan Du (ORCID: https://orcid.org/0000-0003-1952-4042)
- Tao Li (ORCID: https://orcid.org/0000-0002-4913-4486)
- Joseph Wang (ORCID: https://orcid.org/0000-0002-4921-9674)
- Selene Tang (ORCID: https://orcid.org/0009-0002-2007-6128)
- Pengtao Zhang
- Sitao Li
Institutions
- Northern Illinois University (US)
- Argonne National Laboratory (US)
- University of California, Irvine (US)
- University of California San Diego (US)
- La Jolla Bioengineering Institute (US)
- Irvine University (US)
- Washington State University (US)
Publication Details
- Journal
- Med-X
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1007/s44258-024-00027-1
- Citations
- 4
- Primary Topic
- Electrochemical sensors and biosensors
- Type
- article
- Field-Weighted Citation Impact
- 0.83
Funders
- National Science Foundation
- U.S. Department of Energy
- Washington State University
- UC Irvine Materials Research Institute
- Centers for Disease Control and Prevention
- Office of Science
- University of California, San Diego
- University of California, Irvine
- Division of Materials Research
- National Institute for Occupational Safety and Health
- Argonne National Laboratory