Bioinformatics analysis based on extracted ingredients combined with network pharmacology, molecular docking and molecular dynamics simulation to explore the mechanism of Jinbei oral liquid in the therapy of idiopathic pulmonary fibrosis
This work forecasts the prospective core ingredients, targets, and signal pathways of JBOL in anti-IPF, which has confirmed the multiple targets and pathways of JBOL in anti-IPF and provided the first comprehensive assessment with bioinformatic approaches. With empirical backing and an innovative approach to the molecular mechanism, JBOL is being considered as a potential new medication.
Authors
- Qianxi Wang (ORCID: https://orcid.org/0000-0002-0664-5913)
- Aijun Zhang (ORCID: https://orcid.org/0000-0002-2997-6803)
- Jiaxin Tan (ORCID: https://orcid.org/0009-0000-1460-1868)
- Song Liu (ORCID: https://orcid.org/0000-0001-9019-3034)
- Yunjia Wang (ORCID: https://orcid.org/0000-0003-1051-3443)
- Feng Li (ORCID: https://orcid.org/0000-0002-3912-2481)
- Lubo Guo
- Xinru Han
- Zhaoqing Meng
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Jinan Central Hospital (CN)
- Shandong First Medical University (CN)
- Institute of Chinese Materia Medica
Publication Details
- Journal
- Heliyon
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1016/j.heliyon.2024.e38173
- Citations
- 11
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 4.61