An anti-eCIRP strategy for necrotizing enterocolitis
eCIRP exacerbates NEC evidenced by protection with CIRP-deficiency and administration of MOP3, a CIRP-directed therapeutic, in a murine model. Thus, eCIRP is a novel target with human relevance, and MOP3 is a promising treatment for lethal NEC.
Authors
- José M. Prince (ORCID: https://orcid.org/0000-0002-7186-2914)
- Monowar Aziz
- Mariana R. Brewer (ORCID: https://orcid.org/0000-0002-2614-3208)
- Colleen P. Nofi (ORCID: https://orcid.org/0000-0001-5158-3275)
- Ping Wang (ORCID: https://orcid.org/0000-0002-1557-0394)
Institutions
- Northwell Health (US)
- Feinstein Institute for Medical Research (US)
- North Shore University Hospital (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s10020-024-00935-3
- Citations
- 5
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Foundation for the National Institutes of Health