Relationship between p16/ki67 immunoscores and PAX1/ZNF582 methylation status in precancerous and cancerous cervical lesions in high-risk HPV-positive women
Significant heterogeneity was observed in CIN lesions for p16 and Ki67 immunohistochemical staining scores and PAX1/ZNF582 methylation. This may help clinicians personalize the management of CIN based on the predicted short-term risk of cancer progression, minimizing the rate of missed CIN1 diagnoses and incorrect treatment of CIN2/3.
Authors
- Zirong Zhang (ORCID: https://orcid.org/0000-0002-6720-4644)
- Wang Zhi-gan
- Haijun Luo (ORCID: https://orcid.org/0000-0002-0935-6076)
- Hong Tao (ORCID: https://orcid.org/0000-0003-0019-3861)
- Yan Zhao (ORCID: https://orcid.org/0000-0002-8408-2458)
- Yixiang Lian
- Shali Jiang
- Jing Zhou (ORCID: https://orcid.org/0000-0003-4076-4083)
Institutions
- Central South University (CN)
- Changsha Medical University (CN)
- University of South China (CN)
Publication Details
- Journal
- BMC Cancer
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1186/s12885-024-12920-4
- Citations
- 7
- Primary Topic
- Cervical Cancer and HPV Research
- Type
- article
- Field-Weighted Citation Impact
- 2.71