Relationship between depth-wise refractive index and biomechanical properties of human articular cartilage
The results indicate that, although the RI exhibits different levels of correlation with different biomechanical properties, the relationship varies as a function of the tissue depth. This knowledge paves the way for optically monitoring changes in AC biomechanical properties nondestructively via changes in the RI. Thus, the RI could be a potential biomarker for assessing the mechanical competency of AC, particularly in degenerative diseases, such as osteoarthritis.
Authors
- Fatemeh Shahini (ORCID: https://orcid.org/0000-0001-8440-7614)
- Ervin Nippolainen (ORCID: https://orcid.org/0000-0002-1317-2683)
- Bilour Khan (ORCID: https://orcid.org/0000-0003-0633-4709)
- Juha Töyräs (ORCID: https://orcid.org/0000-0002-8035-1606)
- Isaac O. Afara (ORCID: https://orcid.org/0000-0001-7114-0439)
- Alexey Popov (ORCID: https://orcid.org/0000-0002-1417-6715)
- Nonappa Nonappa (ORCID: https://orcid.org/0000-0002-6804-4128)
Institutions
- Tampere University (FI)
- University of Eastern Finland (FI)
- VTT Technical Research Centre of Finland (FI)
Publication Details
- Journal
- Journal of Biomedical Optics
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1117/1.jbo.29.9.095003
- Citations
- 2
- Primary Topic
- Infrared Thermography in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Horizon 2020 Framework Programme