Targeting the cancer cells and cancer‐associated fibroblasts with next‐generation <scp>FGFR</scp> inhibitors in prostate cancer co‐culture models
CAFs exert a protective effect on cancer cells and should be included in the in vitro models to make them physiologically more relevant in screening and testing of FGFRis. The FRS2αi was the most potent agent in reducing the viability and proliferation of the 3D organotypic co-cultures, mainly by disrupting the contact between CAFs and cancer cell clusters. The next-generation FGFRi, FRS2αi, may be a better alternative treatment option for overcoming ARi treatment resistance in advanced PCa.
Authors
- Martin Baumgartner (ORCID: https://orcid.org/0000-0001-9539-7204)
- Pirkko Härkönen (ORCID: https://orcid.org/0000-0001-9440-9971)
- Malin Åkerfelt (ORCID: https://orcid.org/0000-0003-4810-7862)
- Jesse Mattsson
- Syeda Afshan (ORCID: https://orcid.org/0000-0002-2939-8847)
- Yu Gang Kim
- Matthias Nees
Institutions
- Medical University of Lublin (PL)
- Åbo Akademi University (FI)
- University of Turku (FI)
- University Children's Hospital Zurich (CH)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/cam4.70240
- Citations
- 6
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- Ida Montinin Säätiö
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Academy of Finland
- Turun Yliopisto
- Paulon Säätiö
- Swiss Cancer Research Foundation
- Turun Yliopistosäätiö