Mycoplasma Pneumoniae Induced Rash and Mucositis (Mirm): in the Differential Diagnosis of Drug Allergy

Mucocutaneous eruptions associated with Mycoplasma pneumoniae (MP) infection has been newly termed ‘MP-induced rash and mucositis (MIRM)’. A 17-year-old male developed a rash, bilateral purulent conjunctivitis, and oral and genital ulcers after the first dose of amoxicillin-clavulanic acid, initially considered as a drug allergy. Following hospitalization under a preliminary diagnosis of Stevens-Johnson syndrome and initiation of systemic steroids, he developed pneumonia. Laboratory tests confirmed MP infection, leading to a refined diagnosis of MIRM. The patient fully recovered within two weeks following treatment with azithromycin and intravenous immunoglobulin. This case underscores the importance of considering MIRM in the differential diagnosis of drug allergies and aims to enhance awareness of this condition.