Evaluation Of Oxidative Stress And In Non-Diabetic Dyslipidemic Stroke Patients Attending A Tertiary Care Hospital In Eastern India

Introduction: stroke is a clinical syndrome consisting of rapidly developing clinical signs of focal or global disturbance of cerebral function. Antioxidants are the exogenous or endogenous compounds acting by scavenging reactive oxygen species or their precursors, inhibiting reactive oxygen species (ROS) formation and binding metal ions needed for catalysis of ROS generation. Our objective was to compare the lipid profile, fasting and post prandial blood sugar and the markers of lipid peroxidation( malonaldehyde and Paraoxonase1) in non-diabetic stroke patients with healthy controls and to evaluate the correlation between the lipid parameters with markers of lipid peroxidation in those patients Materials and methods: 100 diagnosed stroke patients from Neurology OPD and IPD, were compared with 100 age matched healthy controls. Estimation of lipid profile parameters and fasting and post prandial blood sugar were done by Autoanalyzer using standardized kits. Estimation of serum malonaldehyde was done by based on the principle of utilization of Thiobarbituric acid. Serum Paraoxonase1 activity was estimated using paranitrophenylacetate substrate Result: among the lipid profile parameters, HDL was significantly lower (p<0.001) and LDL was significantly higher among stroke patients. Serum Malonaldehyde level was significantly increased and PON1 activity were significantly decreased in stroke patients in comparison to healthy individuals. Significant positive correlation between HDL and PON1 and negative correlation between LDL and PON1 were found Conclusion: low level of PON1 activity and increased level of malonaldehyde was found in stroke patients indicating imbalance between free radical generation and its scavenging action