Three new flavonoid glycosides from the herbaceous stems of <i>Ephedra intermedia</i>

Phytochemical investigation of the <i>n</i>-butanol extracts of the herbaceous stems of <i>Epheda intermedia</i> led to the isolation of eight flavonoids that included three new flavonoid glycosides (<b>1</b>-<b>3</b>) and five previously reported analogues (<b>4</b>-<b>8</b>). Their structures have been identified on the basis of various spectral data. Besides, all the flavonoids were tested <i>in vitro</i> for their ability to inhibit <i>α</i>-glucosidase under the positive control of acarbose, and the results indicated that none of them exhibited significant inhibitory effect on <i>α</i>-glucosidase at 100 μM.

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Publication Details

Journal
Natural Product Research
Published
2024-09-20
DOI
https://doi.org/10.1080/14786419.2024.2405993
Citations
3
Primary Topic
Pharmacology and Obesity Treatment
Type
article
Field-Weighted Citation Impact
1.34
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article

Three new flavonoid glycosides from the herbaceous stems of Ephedra intermedia

Yingjie Niu, Xiaoke Zheng, Xiang-Da Li, Xinyi Ma et al.
3 citations
Natural Product Research
Pharmacology and Obesity Treatment
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article

Three new flavonoid glycosides from the herbaceous stems of Ephedra intermedia

Yingjie Niu, Xiaoke Zheng, Xiang-Da Li, Xinyi Ma, Xu Chen, Yanling Liu, Di Lu, Yan-Gang Cao, Wei-Sheng Feng
article en
3 citations

Abstract

Phytochemical investigation of the <i>n</i>-butanol extracts of the herbaceous stems of <i>Epheda intermedia</i> led to the isolation of eight flavonoids that included three new flavonoid glycosides (<b>1</b>-<b>3</b>) and five previously reported analogues (<b>4</b>-<b>8</b>). Their structures have been identified on the basis of various spectral data. Besides, all the flavonoids were tested <i>in vitro</i> for their ability to inhibit <i>α</i>-glucosidase under the positive control of acarbose, and the results indicated that none of them exhibited significant inhibitory effect on <i>α</i>-glucosidase at 100 μM.

Natural Product ResearchVol. 40(2)
Ministry of Education (KR), Henan Bioengineering Technology Research Center (CN), First Affiliated Hospital of Henan University (CN)
Zero hunger
Openalex Percentile: Top 19%
Pharmacology and Obesity Treatment
1.34
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