Efficacy, safety and differential outcomes of immune‐chemotherapy with gemcitabine, cisplatin and durvalumab in patients with biliary tract cancers: A multicenter real world cohort
Immuno-chemotherapy in patients with BTC was feasible, effective and safe in a real-life scenario. Our results were comparable to the phase 3 clinical trial results (TOPAZ-1). Reduced efficacy was noted in patients with GB-CA and/or a reduced performance status that warrants further investigation.
Authors
- Arndt Weinmann (ORCID: https://orcid.org/0000-0003-1198-1716)
- Alexander Olkus (ORCID: https://orcid.org/0009-0001-2152-6947)
- Katharina Mitzlaff
- Kornelius Schulze (ORCID: https://orcid.org/0000-0001-7078-9260)
- Fabian Finkelmeier (ORCID: https://orcid.org/0000-0001-8559-9910)
- Michael T. Dill (ORCID: https://orcid.org/0000-0002-1926-4204)
- Lorenz Kocheise (ORCID: https://orcid.org/0000-0002-0036-2234)
- Maria Angeles Gonzalez-Carmona (ORCID: https://orcid.org/0000-0003-3956-1457)
- Bertram Bengsch (ORCID: https://orcid.org/0000-0003-2552-740X)
- Alina Busch
- Michael Quante (ORCID: https://orcid.org/0000-0002-8497-582X)
- Gabriel Allo (ORCID: https://orcid.org/0000-0001-7568-7431)
- Vera Himmelsbach
- Maryam Barsch (ORCID: https://orcid.org/0000-0003-3983-8276)
- Martha M. Kirstein (ORCID: https://orcid.org/0000-0001-9415-4083)
- Marino Venerito (ORCID: https://orcid.org/0000-0001-8581-0974)
- Christian Müller (ORCID: https://orcid.org/0000-0002-6881-1817)
- Roman Kloeckner (ORCID: https://orcid.org/0000-0001-5492-4792)
- Jens U. Marquardt (ORCID: https://orcid.org/0000-0002-8314-2682)
- Peter Schirmacher
- Dirk‐Thomas Waldschmidt
- Carolin Zimpel
Institutions
- Goethe University Frankfurt (DE)
- Universität Hamburg (DE)
- German Cancer Research Center (DE)
- University of Cologne (DE)
- Johannes Gutenberg University Mainz (DE)
- Heidelberg University (DE)
- University Hospital Bonn (DE)
- University Medical Center Freiburg (DE)
- University Hospital Heidelberg (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- National Center for Tumor Diseases (DE)
- University Hospital Frankfurt (DE)
- University Hospital Magdeburg (DE)
- University Hospital Cologne (DE)
- University of Lübeck (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- United European Gastroenterology Journal
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1002/ueg2.12656
- Citations
- 14
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 8.02