The role of HLA-B27 in cancer immunity: Investigating its potential impact on tumour surveillance and response to immunotherapy

This research paper specifically aims at identifying HLA-B27’s involvement in the anti-cancer immune response and response to immunotherapy especially in tumor detection. Hydroxylation of HLA-B27 may affect the immune system and chronic inflammation, which is responsible for cancer predisposition due to the molecule. The literature on the relationship between HLA-B27 and cancer forms and types is analyzed with the focus on the immunological and genetic mechanisms in the contexts of brain cancer. It points out the directions for the literature by outlining significant areas for further research to explain these mechanisms. The results have the following practical importance regarding the screening and individual approach this field is interested in improving the prevention and treatment of cancer for patients with HLA-B27 positive.