Optical coherence tomography angiography enables visualization of microvascular patterns in chronic venous insufficiency
Chronic venous insufficiency (CVI) is a global health concern with significant public health and individual impact. Currently available diagnostic methods cannot visualize microvenous pathologies that have shown to result in severe forms of CVI and also affect the skin. Optical coherence tomography angiography (OCTA) may close the CVI diagnostic gap by providing a fast, label-free, and non-invasive solution to visualize cutaneous microvasculature. The study enlisted 66 subjects, including 53 CVI patients spanning all clinical-etiology-anatomic-pathophysiologic (CEAP) C stages and 13 healthy controls. The high spatial resolution OCTA system used was specifically designed for skin imaging. Significant microangiographic pattern variations emerged, both in qualitative and quantitative terms. OCTA provided valuable insights into cutaneous microvascular changes among different CVI stages. Thereby, OCTA may enable the selection of patient populations at risk for disease progression in the future.
Authors
- Kristen M. Meiburger (ORCID: https://orcid.org/0000-0002-7302-6135)
- Julia Deinsberger (ORCID: https://orcid.org/0000-0002-4237-1526)
- Leopold F. Schmetterer (ORCID: https://orcid.org/0000-0002-7189-1707)
- Benedikt Weber (ORCID: https://orcid.org/0000-0002-7217-4590)
- Wolfgang Drexler (ORCID: https://orcid.org/0000-0002-3557-6398)
- Christoph Sinz (ORCID: https://orcid.org/0000-0001-5589-1865)
- Giulia Rotunno (ORCID: https://orcid.org/0000-0003-4239-5816)
- Valentin Häcker (ORCID: https://orcid.org/0000-0003-0046-5804)
- Rainer A. Leitgeb (ORCID: https://orcid.org/0000-0002-0131-4111)
- Richard Haindl (ORCID: https://orcid.org/0000-0003-3471-0986)
- Lisa Krainz (ORCID: https://orcid.org/0000-0003-4436-8205)
- Lukasz Bugyi
- Mengyang Liu (ORCID: https://orcid.org/0000-0002-8862-5966)
Institutions
- Nanyang Technological University (SG)
- Politecnico di Torino (IT)
- Singapore Eye Research Institute (SG)
- Duke-NUS Medical School (SG)
- Institute of Molecular and Clinical Ophthalmology Basel (CH)
- Medical University of Vienna (AT)
Publication Details
- Journal
- iScience
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1016/j.isci.2024.110998
- Citations
- 3
- Primary Topic
- Diagnosis and Treatment of Venous Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Vienna Science and Technology Fund
- Austrian Science Fund
- Universität Wien
- Medizinische Universität Wien
- Horizon 2020 Framework Programme
- H2020 Marie Skłodowska-Curie Actions
- H2020 LEIT Information and Communication Technologies