Development of Eutectics of Pioglitazone with Citric Acid and its Effect on Crystallite Properties and Dissolution

Eutectics of pioglitazone were developed using citric acid (CA) as the co-former, and the effect on crystallite properties and dissolution has correspondingly been studied. Pioglitazone-citric acid eutectics (PC1, PC2, PC3, and PC4) in different molar ratios (3:1, 3:2, 1:1, and 3:4 respectively) were prepared by simple solvent evaporation method. Difference in dislocation density and strain value of the eutectics were observed, and the maximum strain value of PC1 might be due to the highest deformation activity compared to PC2, PC3, and PC4. Carbonyl-thiazolidine or carboxyl-pyridine weak bond formation might be the reason of producing eutectics of PGZ-CA rather than cocrystal with a docking score of - 2.2 Kcal/M. Likewise, lowest particle size was found with PC1 rather than that of pure PGZ and other eutectics. PC1 demonstrated highest dissolution of drug (68 %) rather than other eutectics (54 to 61 %) and PGZ (44 %) after 360 min.

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Publication Details

Journal
Acta chimica slovenica
Published
2024-09-20
DOI
https://doi.org/10.17344/acsi.2024.8793
Primary Topic
Crystallization and Solubility Studies
Type
article
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article

Development of Eutectics of Pioglitazone with Citric Acid and its Effect on Crystallite Properties and Dissolution

Sk Habibullah, Rakesh Swain, Subrata Mallick, Souvik Nandi et al.
Acta chimica slovenica
Crystallization and Solubility Studies
article

Development of Eutectics of Pioglitazone with Citric Acid and its Effect on Crystallite Properties and Dissolution

Sk Habibullah, Rakesh Swain, Subrata Mallick, Souvik Nandi, Rudra Narayan Sahoo, Rasmita Dash, Mouli Das, Shibashis Panigrahy, Tanisha Das
article en

Abstract

Eutectics of pioglitazone were developed using citric acid (CA) as the co-former, and the effect on crystallite properties and dissolution has correspondingly been studied. Pioglitazone-citric acid eutectics (PC1, PC2, PC3, and PC4) in different molar ratios (3:1, 3:2, 1:1, and 3:4 respectively) were prepared by simple solvent evaporation method. Difference in dislocation density and strain value of the eutectics were observed, and the maximum strain value of PC1 might be due to the highest deformation activity compared to PC2, PC3, and PC4. Carbonyl-thiazolidine or carboxyl-pyridine weak bond formation might be the reason of producing eutectics of PGZ-CA rather than cocrystal with a docking score of - 2.2 Kcal/M. Likewise, lowest particle size was found with PC1 rather than that of pure PGZ and other eutectics. PC1 demonstrated highest dissolution of drug (68 %) rather than other eutectics (54 to 61 %) and PGZ (44 %) after 360 min.

Acta chimica slovenicaVol. 71(3)
Toshiba (Japan) (JP), Siksha O Anusandhan University (IN), Samudra University (ID), North American Skull Base Society (US), Development Agency of Serbia (RS), Ferghana State University (UZ), Burke Foundation (US), Université de Saida Dr.Moulay Tahar (DZ), University of Rajshahi (BD)
Openalex Percentile: Top 90%
Crystallization and Solubility Studies
DOIOpen Access PDFOpenAlex
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Development of Eutectics of Pioglitazone with Citric Acid and its Effect on Crystallite Properties and Dissolution — Sk Habibullah, Rakesh Swain, et al. · Acta chimica slovenica (2024) | TGRS Research Map | TGRS