Higher sensitivity of pericardial fluid cytology than biopsy in malignant effusions with potential explanation of false‐negative cytology: A multi‐institutional analysis
This study demonstrated diagnostic superiority of pericardial fluid cytology over biopsy in the evaluation of malignant pericardial effusions. We identified several limitations in fluid cytology causing false negatives. In the context of an underlying malignancy with pericardial effusion, pathologists should consider immunohistochemistry studies to aid on the diagnosis.
Authors
- Weijie Ma (ORCID: https://orcid.org/0000-0002-4434-1371)
- Haiming Tang (ORCID: https://orcid.org/0000-0001-7058-349X)
- Eric C. Huang (ORCID: https://orcid.org/0000-0002-8745-0025)
- Jocelyn Chandler (ORCID: https://orcid.org/0000-0002-7218-3286)
- Isabela Delfino
- Mayara Bearse
- Xiaoqi Lin (ORCID: https://orcid.org/0000-0002-0760-3950)
- Catherine Gereg
- He Wang (ORCID: https://orcid.org/0000-0001-9736-8028)
- Kotaro Takeda (ORCID: https://orcid.org/0000-0002-9376-9817)
- Xiaoying Liu
Institutions
- Northwestern University (US)
- Dartmouth–Hitchcock Medical Center (US)
- Yale New Haven Hospital (US)
- University of Washington (US)
- Yale University (US)
- Northwestern Memorial Hospital (US)
- Universidade de Uberaba (BR)
Publication Details
- Journal
- Cytopathology
- Published
- 2024-09-20
- DOI
- https://doi.org/10.1111/cyt.13447
- Citations
- 2
- Primary Topic
- Pericarditis and Cardiac Tamponade
- Type
- article
- Field-Weighted Citation Impact
- 0.80