Malignant salivary gland tumors of the tongue: <scp>A</scp> multicenter <scp>REFCOR</scp> study

Salivary carcinomas of minor salivary glands are very infrequent tumors. When located in the tongue, the therapeutic strategy may comprise upfront surgery, which may be debilitating, and/or (chemo-)radiotherapy. The aim of this study was to identify the prognostic factors of salivary carcinomas of the tongue in a population-based cohort. This retrospective multicentric study, based on the "Réseau d'Expertise Français sur les Cancers ORL Rares" (REFCOR), included all the patients with a salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Dubious slides were reviewed by REFCOR expert pathologists to ensure diagnostic accuracy. Treatment was performed in accordance with national REFCOR recommendations. From 28 centers, 103 patients were included in this study. Median age at diagnosis was 63 years, and 60.2% were female. Tumors were adenoid cystic carcinomas (41.7%), mucoepidermoid carcinomas (30.1%), and other adenocarcinomas (28.2%). Primary treatment was surgical for 61.2% of them. Five-year overall survival (OS) and event-free survival (EFS) rates were 84.7% and 38.6%, respectively. In multivariable analysis, EFS was significantly worse in case of nonsurgical treatment, alcohol consumption, and glossotonsillar sulcus involvement. N-positive status was the only significant prognostic factor for OS in multivariable analysis. Salivary carcinomas of the tongue represent a heterogeneous group of rare tumors, with a high risk of recurrence. In this national cohort, surgery was associated with better EFS and N-status was the main independent prognostic factor for OS.

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Journal
International Journal of Cancer
Published
2024-09-20
DOI
https://doi.org/10.1002/ijc.35167
Citations
2
Primary Topic
Salivary Gland Tumors Diagnosis and Treatment
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article
Field-Weighted Citation Impact
1.15
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article

Malignant salivary gland tumors of the tongue: A multicenter REFCOR study

Vianney Bastit, Robin Baudouin, Lionel Ramin, F. Mouawad et al.
2 citations
International Journal of Cancer
Salivary Gland Tumors Diagnosis and Treatment
1.15
article

Malignant salivary gland tumors of the tongue: A multicenter REFCOR study

Vianney Bastit, Robin Baudouin, Lionel Ramin, F. Mouawad, Xavier Dufour, Charles Dupin, R. Garrel, Diane Evrard, Philippe Ceruse, Pierre Ransy, Chloé Bertolus, S. Vergèz, S. Morinière, Jean‐Paul Marie, É. Chabrillac, Esteban Brenet, H. Mirghani, Nicolas Fakhry, O. Malard, Sarah Atallah, Florian Chatelet, Philippe Schultz, Suzy Duflo, Emmanuelle Uro‐Coste, Florence Jourdan‐Soulier, Dorian Culié, Valentine Poissonnet, A. Modesto, Bertille Segier, D.T. Nguyen, Franck Jegoux, Christian Righini, Caroline Even
article en
2 citations

Abstract

Salivary carcinomas of minor salivary glands are very infrequent tumors. When located in the tongue, the therapeutic strategy may comprise upfront surgery, which may be debilitating, and/or (chemo-)radiotherapy. The aim of this study was to identify the prognostic factors of salivary carcinomas of the tongue in a population-based cohort. This retrospective multicentric study, based on the "Réseau d'Expertise Français sur les Cancers ORL Rares" (REFCOR), included all the patients with a salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Dubious slides were reviewed by REFCOR expert pathologists to ensure diagnostic accuracy. Treatment was performed in accordance with national REFCOR recommendations. From 28 centers, 103 patients were included in this study. Median age at diagnosis was 63 years, and 60.2% were female. Tumors were adenoid cystic carcinomas (41.7%), mucoepidermoid carcinomas (30.1%), and other adenocarcinomas (28.2%). Primary treatment was surgical for 61.2% of them. Five-year overall survival (OS) and event-free survival (EFS) rates were 84.7% and 38.6%, respectively. In multivariable analysis, EFS was significantly worse in case of nonsurgical treatment, alcohol consumption, and glossotonsillar sulcus involvement. N-positive status was the only significant prognostic factor for OS in multivariable analysis. Salivary carcinomas of the tongue represent a heterogeneous group of rare tumors, with a high risk of recurrence. In this national cohort, surgery was associated with better EFS and N-status was the main independent prognostic factor for OS.

International Journal of CancerVol. 156(2)
Université de Tours (FR), Inserm (FR), University of Liège (BE), Centre Hospitalier Universitaire de Grenoble (FR), Institut Gustave Roussy (FR), Centre Hospitalier Universitaire de Bordeaux (FR), Université de Poitiers (FR), Sorbonne Université (FR), Assistance Publique Hôpitaux de Marseille (FR), Centre Hospitalier Universitaire de Montpellier (FR), Centre Hospitalier Universitaire de Tours (FR), Assistance Publique – Hôpitaux de Paris (FR), Institut universitaire du cancer de Toulouse Oncopole (FR), Centre Hospitalier Régional et Universitaire de Nancy (FR), Hospices Civils de Lyon (FR), Hôpital Européen Georges-Pompidou (FR), Centre Hospitalier Universitaire de Reims (FR), Hôpital Lariboisière (FR), Pitié-Salpêtrière Hospital (FR), Hôpital Larrey (FR), Institut Claudius Regaud (FR), Hôpital Bichat-Claude-Bernard (FR), Centre Hospitalier Universitaire de Rennes (FR), Hôpital Foch (FR), Hôpital Tenon (FR), Université de Rouen Normandie (FR), Université de Limoges (FR), Université de Strasbourg (FR), Université Grenoble Alpes (FR), Université de Reims Champagne-Ardenne (FR), Université de Caen Normandie (FR)
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Salivary Gland Tumors Diagnosis and Treatment
1.15
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